Lil' Bush cracks satirical jokes at the Bush administration. The show depicts the administration members as pint-size cartoon characters. The title character is accompanied by Lil' Cheney and Lil' Condi.
When Lil' Vladimir Putin and Lil' George start a schoolyard rivalry, it escalates to Lil' Putin poisoning Lil' George, whose head swells to five times its normal size. After some training from former wrestling champ Barbara Bush, Lil' George faces off against Lil' Putin in a classic playground battle. Meanwhile, Lil' Cheney has been partnered with Lil' Nancy Pelosi, and given a watermelon to care for as their child. When it becomes apparent that their watermelon is a lesbian, Lil' Cheney has some hard choices to make.
